Collectively our findings suggest that peripheral sensory neurons have a major impact in the development and progression of psoriasis in a preclinical animal model, and propose a molecular pathway by which RvD3 acts on the receptor ALX/FPR2 in DRG neurons controlling TRPV1 activity and CGRP release to attenuate both psoriasiform itch and skin inflammation in mice (Figure 7A). Here, TRPV1 is linked to psoriasis.