In addition, based on a GEO dataset (GSE79637) of HNSCC specimens, YTHDF1 expression was more prominent in highly metastatic lines (FaDu origin: hypopharynx, Detroit 562 origin: pleural effusion) than in nonmetastatic lines (YCU-OR891 origin: oral floor, YCU-MS861 origin: maxillary sinus) (Figure 3B). Here, YTHDF1 is linked to head and neck squamous cell carcinoma.