In addition, it has been reported that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an AhR-related inducer of the cytochrome P450 1A1 (CYP1A1), enhances the DNA binding activity of nuclear factor-kappaB (NF-κB) and activator protein-1 (AP-1) in macrophages during inflammation or sepsis 50, 51. Here, NFKB1 is linked to Sepsis.