Therefore, EBV appears to lead the NPC cells to undergo a process of “Redox Resetting” to acquire a new redox status to tolerate higher levels of ROS accumulation and stronger antioxidant systems by increasing the expression of the ROS-producing enzyme, NOX2, and the cellular master antioxidant regulator, Nrf2. The gene discussed is CYBB; the disease is nasopharyngeal carcinoma.