SLC38A7 and brain glioma: When compared to the amino-acid PET tracer 11C-MET, which did not show a correlation between uptake and outcome 22, our findings suggest that in DIPGs 18F-DOPA uptake might be related to additional mechanisms, such as expression of supplementary amino-acid transporters, as demonstrated in a prior study where 18F-DOPA uptake values of brain gliomas were not exclusively dependent on L-type amino-acid transporter (LAT) 1 expression 31,32.