For example, Ho et al. deduced that the upregulation of TREM-1 expression in cultured lung cancer cells enhances the tumor cell invasion potential via mediating the bulky expressions of NF-κB and TNF-α, and the expression inhibition of TREM-1 by shRNA evidently reduced the cell invasion ability of the tumors [60]. This evidence concerns the gene NFKB1 and lung cancer.