BCL2 and cancer: Other studies of anticancer effects of DMC on different cancer cell lines (K562 (leukemia cells) or PANC-1 (pancreatic cancer cells)) also indicated that the chalcone could lower Bcl-2/Bax ratio by decreasing the expression of Bcl-2 gene and activating caspase-3 and caspase-9 [39, 46].