In addition, baicalein inhibits human rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) proliferation involving suppression of nuclear factor kappa B (NF-κB) transcriptional activity and recombinant macrophage migration inhibitory factor- (MIF-) mediated signaling [61]. The gene discussed is NFKB1; the disease is rheumatoid arthritis.