The mechanism of removing jaundice and increasing choleresis may be the upregulation of the expression of multidrug resistance transporters Mrp2 and Mrp3 in the hepatocyte membrane and the enhancing of the excretion capability of hepatocytes with cholestasis [34], thereby reducing the accumulation of bilirubin and cholate in the hepatocytes [35]. The gene discussed is ABCC3; the disease is cholestasis.