CRP and infection: This was confirmed by Gilfillan and Bhandari [9] who reported that presepsin rises almost 2–12 hours after the onset of infection, while nCD64 rises 1–6 hours after the sepsis onset; however, CRP rises later than both nCD64 and presepsin which rises 12–24 hours after infection and peaks at 36–48 hours and then drops dramatically with antibiotic treatment which makes CRP less than ideal for early sepsis diagnosis.