INS and Insulin resistance: Despite the study failed in detecting improvement of insulin-resistance indexes, HOMA-IR, and Matsuda Index as well as of insulin sensitivity index QUICKI, one month after a single 60 mg Dmab injection, FGF21 levels were significantly reduced, consistently with the improvement of hepatic insulin sensitivity, and Dmab inhibitory effect on FGF21 was detectable also 5 months later.