For these different reasons, several studies have shown that the regulation of these different pathways can be a solution for new therapeutic approaches against ulcerative colitis; thus, resveratrol exerts its effect against ulcerative colitis by increasing the expression of the SIRT1 gene, inducing the drop in the expression of p-IkBα as well as of COX-2 [52], while proto-catechic acid inhibits the production of inflammatory cytokines as well as COX-2 and iNOS to relieve patients with ulcerative colitis [53]. The gene discussed is NFKBIA; the disease is ulcerative colitis.