Diabetes induced significant increases in the concentration of the bone resorption marker CTX-I (by 503.9% in the nonovariectomized rats and by 325.9% in the ovariectomized rats in relation to the appropriate nondiabetic controls) and decreases in that of the bone formation marker osteocalcin (by 51.5% in the nonovariectomized rats and by 72.7% in the ovariectomized rats in relation to the appropriate nondiabetic controls) (Figure 3). This evidence concerns the gene BGLAP and diabetes mellitus.