Probably, MMP8 triggers migration- and invasion-suppressive molecular cascades through cleavage of various non-ECM substrates with specific regulatory functions.172 Similarly, mutations in the gene encoding a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs (ADAMTS18) are potential drivers of melanoma and promote the migration of A375 melanoma cells in vitro and the metastasis of Mel-STR cells in vivo.173 Notably, however, evidence exists that mutations in protease genes can confer an inhibitory effect on the movement of tumour cells. The gene discussed is MMP8; the disease is melanoma.