Thus, each of these p53 mutants may specifically affect the metastatic ability of cancer cells.86 In contrast, the p53 R248Q mutant negatively affects the migration of MDA-MB-231 breast and H1299 lung cancer cells in vitro and alters the distribution of MDA-MB-231 cells injected into zebrafish embryos, and contributes to mesenchymal–epithelial transition (the opposite of EMT).87 More research is therefore needed to understand the effects of different p53 GOF mutations on tumour cell motility and invasiveness. This evidence concerns the gene TP53 and lung cancer.