RHOA and melanoma: This can indicate that RAC1 P29S-harbouring melanoma cells have an enhanced migration, but attenuated invasion.141RHOA is a driver gene in many cancers, such as T-cell lymphoma and gastric cancer.142 LOF mutants of RHOA (G17E, Y42C and Y42S) that are present in diffuse-type stomach cancers lead to the inactivation of RhoA–ROCK1 signalling and increased migration of MKN74 gastric tubular adenocarcinoma cells in vitro.143 Moreover, as shown in the orthotopic xenograft mouse model, MKN74 gastric cancer cells with RHOA mutations are more invasive and acquire immune resistance.144