YAP1 and neoplasm: The MLL–AF9 translocation t(9;11) is found in acute myeloid leukaemia and promotes tumour invasion associated with the transcription factor ZEB1 in a long-term haematopoietic stem-cell-derived mouse model of acute myeloid leukaemia.43 Fusions between the oestrogen receptor gene (ESR1) and YAP1 (which encodes Yes1-associated transcriptional regulator) or PCDH11X (which encodes the cell adhesion protein protocadherin 11 X-linked) are associated with the induction of EMT and were shown to enhance the motility of T47D breast cancer cells in vitro and the metastasis of T47D xenografts.44