Surprisingly, wild-type MMP8 inhibits melanoma cell migration.169 Migration and invasion-suppressive role of MMP8 are also known in oral tongue squamous cell and breast carcinomas.170,171 Moreover, in breast cancer, MMP8 can prevent metastasis formation.171 The exact mechanisms of the suppressive effects of MMP8 are still unclear. The gene discussed is MMP8; the disease is breast cancer.