The ERK3 L290P/V mutation promotes the migration and invasion but not proliferation of H1299 and A549 NSCLC cells in vitro.110 Loss of MKK4 protein due to MAP2K4 LOF mutations enhances the invasion associated with peroxisome proliferator-activated receptor γ (PPARγ) of various lung cancer cell lines (344SQ, 393P and H2009) in vitro.111. Here, MAP2K4 is linked to lung cancer.