TP53 and cancer: For example, local invasion is a hallmark of malignant gliomas, making glioma cells a candidate model for finding drivers of cancer invasion.194 However, data also indicate that highly dynamic cells are present not only at tumour borders but also in the tumour core, as was demonstrated in NICD/p53−/− mouse intestinal cancer195 and orthotopic human glioblastoma model,196 which significantly reduces the chance of finding mutations that drive cancer invasion when comparing the invasive front with the tumour core.