In a proof of concept study, patients are treated with the histone deacetylase inhibitor vorinostat for 14 days upon resistance and thereafter BRAF and/or MEK inhibitors are reintroduced.27 This cohort contains unique data on paired molecular analyses in tumour tissue for patients with BRAFV600E mutant metastatic CRC treated with encorafenib and cetuximab with or without binimetinib or alpelisib. This evidence concerns the gene MAP2K7 and colorectal carcinoma.