Several candidate targets exist, which, when inhibited, might block this mechanical interaction and prevent tumour cell plasticity, including integrins,134,135 vimentin,136 Rho/ROCK and actomyosin contractility137 and FAK.36,134,135,138 Notably, however, interfering with tumour–TME interactions can also have unexpected and undesirable effects. The gene discussed is VIM; the disease is neoplasm.