Of the 28 biomarkers that were investigated, sTNFR1 and H-FABP had the highest AUROC pre surgery to stratify risk of AKI in orthopaedic trauma patients (Table 2) (sTNFR1 sensitivity 76.4%; specificity 59.7%; AUROC 0.729 (CI 0.654–0.804); H-FABP sensitivity 62.1%; specificity 71.2%; AUROC 0.712 (CI 0.637–0.786) (Fig. 2A,B)). The gene discussed is FABP3; the disease is acute kidney injury.