Disruption to dopaminergic neurotransmission is a central characteristic of schizophrenia, and while overactivity of distributed dopamine networks with influences of the dopamine D2-like receptor family (e.g., D2, D3, and D4 receptors) is putatively involved in the primary psychotic manifestations of the disease, activation of dopamine D1 receptors has been recommended as a target for the investigation of treatment of cognitive impairment associated with schizophrenia (CIAS) [7]. This evidence concerns the gene DRD1 and schizophrenia.