Cluster of differentiation 146 (CD146, also known as melanoma cell-adhesion molecule) is a member of the immunoglobulin superfamily and has been identified as a novel endothelial biomarker that acts as a vascular endothelial growth factor coreceptor and plays a key role in tumor-related angiogenesis.15,16 CD146 is primarily expressed at the intercellular junctions of endothelial cells. This evidence concerns the gene MCAM and neoplasm.