We compared frequency of TP53 mutations and common chromosomal aberrations (5q and 7q deletions) between XP-C leukemia and adult de novo acute myeloid leukemia cohort15 (AML); and found that TP53 was mutated significantly more often in our dataset (5/6 cases and 15/200 cases for XP-C and sporadic AML respectively, P = 2.963e−05, odds ratio = 58.66, 95% CI = 6.04−2872.04; Fisher’s exact test, two-sided). Here, XPC is linked to acute myeloid leukemia.