NPHS2 and focal segmental glomerulosclerosis: To investigate the relationship between YAP nuclear exclusion and podocyte apoptosis in the progression of FSGS, an Adriamycin-induced FSGS mouse model was constructed (Fig. 2A) by using mT/mG; NPHS2-Cre mice, which were generated as illustrated in the “Materials and methods” (We used 17 mg Adriamycin/kg body weight for its safety and efficiency; see Supplementary Fig. 1A, B for more about creation of the model).