Untargeted lipidomic profiling on xenograft tumour samples revealed that the levels of PA were remarkably increased, while the levels of DAG were significantly decreased in nude mice implanted with LPIN1-KO MDA-MB-231 cells reconstituted with WT-lipin-1 or 3YF-lipin-1 (Supplementary Fig. 8s, t and Supplementary Data 1). This evidence concerns the gene LPIN1 and neoplasm.