Furthermore, analysis of a recent spatial transcriptomics18 study19 (https://als-st.nygenome.org/) investigating gene expression changes following amyotrophic lateral sclerosis indicates a similar spatial distribution of Klk6 and Hopx (MOL2) as well as Ptgds (MOL5/6) and Il33 genes (MOL6) (Supplementary Fig. 3e) as we report here. Here, KLK6 is linked to amyotrophic lateral sclerosis.