ABCB1 and neoplasm: Although cell ferroptosis can be distinguished from apoptosis in many ways, two major differences can be pointed out: (1) ferroptosis is directly or indirectly caused by an iron-death initiator, and lipid peroxide (LPO) severely damages cell integrity and structure17; (2) Ferroptosis bypasses apoptosis inhibition, avoiding the induction of membrane-specific proteins (such as P-glycoprotein and multi-resistant-related protein family) related to multidrug resistance, which may provide novel insights into the development of chemo-resistant tumor therapy31.