ALOXE3 and cancer: The present study not only discovered a new function of TalaA—its ability to kill tumor cells via ferroptosis induction, but also elucidated its molecular pharmacological mechanism of upregulated expression of molecules (such as ALOXE3 and HMOX1), which promotes lipid peroxidation and suppresses the expression of antioxidant-related molecules (such as SLC7A11 and GSS), thereby causing cancer cell death by ferroptosis induction (Fig. 8).