In humans, NALCN variants are linked to a variety of diseases known as NALCN channelopathies, including congenital contractures of the limbs and face, hypotonia and developmental delay (CLIFAHDD)19–21, psychomotor retardation and characteristic facies (IHPRF)22,23, infantile neuroaxonal dystrophy (INAD)24, cervical dystonia, schizophrenia and bipolar disorder25–27. The gene discussed is NALCN; the disease is neurodegeneration with brain iron accumulation 2A.