Recent studies have shown that tumor-derived cytokines (granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF)) induce the upregulation of lipid transport receptors in tumor-infiltrating MDSCs, which triggers lipid influx, LD biogenesis, and oxidative metabolism. The gene discussed is CSF2; the disease is neoplasm.