MKI67 and neoplasm: To confirm that these changes occurred in the tumor cells, we examined Ki67 IHC, recapitulating that the greatest proliferation reduction was seen with TL, followed by L, followed by T: the geometric mean of Ki67 percentage changed across treatment from 29.8% to 11.4% with TL (N = 25; p = 0.0016), from 23.8% to 17.3% with L (N = 21; p = 0.13), and from 25.9% to 23.1% with T (N = 21; two-sided paired t-test of the log2 Ki67 values p = 0.17) (Fig. 3f).