ESR1 and neoplasm: Both ERBB2 signaling and ESR1 signaling were anti-correlated with immune infiltration and stromal infiltration, making it difficult to disentangle whether their observed decreases were solely a result of a reduction in tumor content relative to other cell types (with less ERBB2 and ESR1 signaling), or whether the tumor cells independently experienced a reduction in the activation of these pathways in response to treatment.