EFNA5 and Autoimmunity: For instance, there were receptors/ligands significantly altered in almost all cell–cell communications in the disease state, such as the down-regulated EFNA5/EPHA4 (Fig. 6d) and up-regulated IL10/IL10RA interleukin signaling pathways (Fig. 6e), whose dysregulation may increase risk for many autoimmune diseases42,43, yet the epigenetic mechanism of these pathways driving the autoimmunity and tissue fibrosis has yet been fully uncovered.