A “TF footprint” analysis of our ATAC-seq profiles revealed distinct TFs NFκB and STAT footprints on genomic DNA directly from clinical SSc affected DCs versus normal cells (Fig. 4j), suggesting a more pronounced DNA occupancy of NFκB and STAT1 in DCs from affected SSc skin than their normal counterpart. The gene discussed is SOAT1; the disease is systemic sclerosis.