Moreover, KD of DEPDC1B significantly inhibited cell proliferation of bladder cancer, and promoted cell apoptosis through the regulation of Caspase-3, clAP-2, IGF-I, IGFBP-2, IGF-1sR, Livin, TNF-β, TRAILR-3, and TRAILR-4. Here, DEPDC1B is linked to urinary bladder carcinoma.