TTR and amyloidosis: Glycosylation is a viable candidate to consider for an initiating event in TTR amyloidosis because (a) it is commonly involved as a post translational signal in biochemical pathways to activate or moderate metabolic pathways [75], (b) glycosylation activity in human plasma is heavily influenced by gender [73], (c) there is a general decrease in glycosylation activity with age [76].