IFNA1 and enterovirus infectious disease: As some transformed cells with defects in IFN signaling and altered innate immune signaling have been reported (34), we initially selected and evaluated 7 human IEC lines including 2 human normal IEC lines (FHC and HCoEpiC) and 5 human cancerous IEC lines (HT29, HCT116, DLD1, LoVo, and SW48), which are suitable for enterovirus infection as described previously (34).