Similarly, the levels of IFN-λ1 mRNA (Fig. 6F), IFN-λ2/3 mRNA (Fig. 6G), and IFN-λ1 protein (Fig. 6H) were upregulated in HT29 cells upon the infections with CVB3 and PV1, while the productions of type III IFNs mediated by CVB3 and PV1 were attenuated by shIRF1 (Fig. 6F to H). The gene discussed is IFNL1; the disease is infection.