Infection of FHC and HT29 cells with EV71 triggered an obvious increase in IFN-λ1 and IFN-λ2/3 (type III IFNs) mRNAs, but no upregulation of IFN-α and IFN-β (type I IFNs) mRNAs (Fig. 1C and D). This evidence concerns the gene IFNL2 and infection.