CM isolates overexpressed EPCR-binding domains (CIDRα1.1, CIDRα1.4-8) and DBLα domains upstream (DBLα2/1.1/2/4/7) in accordance with the literature, confirming the major role of EPCR in CM pathophysiology (15, 17, 18). This evidence concerns the gene PROCR and cutaneous mastocytosis.