It has been shown that DMBA can promote a more invasive, mesenchymal phenotype in the Rel-3983 cell line, a cell line established from a mouse mammary tumor virus (MMTV)-c-rel transgenic mouse model constructed to test, directly, the role of the nuclear c-Rel subfamily of NF-κB proteins in breast cancer [52]. Here, NFKB1 is linked to breast cancer.