Authors concluded that BP1 and NP may accelerate growth of MCF-7 breast cancer cells by regulating cell cycle-related genes and promote cancer metastasis through amplification of cathepsin D. Similar results concerning the effects of BP1 were found in BG1 human ovarian cancer cells which express the ER with the up-regulation of cyclin D1 [73]. The gene discussed is ESR1; the disease is breast cancer.