Interestingly, cancer genes CDH13 and BCAR1 were found with multiple KRT DhMRs, and they were also important genes for hyper-5hmC in HPV(−) tumors, which is consistent with the previous finding that the KRT subtype shares more similarities with HPV(−) HNSCC. The gene discussed is CDH13; the disease is head and neck squamous cell carcinoma.