Hence, the study is intended to probe into the mechanism translation of HDAC3, miR-296-3p, TGFβ signaling pathway and TGIF1 in CRC and it is elucidated that HDAC3 deteriorates CRC progression and promotes tumor growth via miR-296-3p/TGIF1/TGFβ axis. The gene discussed is HDAC3; the disease is colorectal carcinoma.