Age (P = 0.010), chronic steroid use (P = 0.003), preoperative albumin level < 3.5 g/dl (P = 0.001), spondylolisthesis diagnosis (P = 0.001), postoperative albumin level < 3.5 g/dl (P < 0.001), postoperative albumin level < 3.0 g/dl (P < 0.001), length of stay (P < 0.001), and hospitalization expenses (P < 0.001) were significantly correlated with the incidence of SSI. This evidence concerns the gene ALB and spondylolisthesis.