Regarding the infection related index, two of the P2 patients (25%) showed increased total bilirubin (P < 0.05 by χ2 test), and eight of the P2 patients (100%) had increased C-reactive protein levels (P < 0.05 by χ2 test) compared with much lower percentages of 21.7 and 15.2% in P3 and P4 groups, respectively. This evidence concerns the gene CRP and infection.