A higher expression of the pro-inflammatory markers such as IL-6, TNF-α, C-reactive protein (CRP), cyclooxygenase 2 (COX-2), leptin, serum amyloid 1 (SAA1) and IL-8 were inversely associated with completed lobular involution while a higher expression of the anti-inflammatory marker interleukin 10 (IL-10) [137] was positively associated with mammographic density, another well-known breast cancer risk factor [14]. Here, TNF is linked to breast cancer.