Similarly, in an older study, EFT of COPD patients (n = 171) was significantly higher than controls (n = 70) (143.7 vs. 129.1 cm3; p = 0.02) and was correlated with CRP (r = 0.32; p < 0.001) and coronary calcium score (r = 0.38; p < 0.001) [99]. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.