Leptin and adiponectin levels may vary according to COPD phenotypes (e.g., in relation to emphysema development and progression) [30] and their circulating levels may be affected by statins and antidiabetic drugs (metformin, pioglitazone, empagliflozin and liraglutide) [31,32,33]. The gene discussed is LEP; the disease is chronic obstructive pulmonary disease.