Interestingly, the ratio of Ser(P)-1292 LRRK2 to total LRKK2 is increased in urinary EVs of PD patients with and without LRKK2 mutations, whereby the Ser(P)-1292 LRRK2 levels in the latter group correlate with several non-motor aspects of PD [169,170]. The gene discussed is LRRK2; the disease is Parkinson disease.