SREBF1 and metabolic dysfunction-associated steatotic liver disease: Their biological effects on NAFLD have been characterized in terms of lipid metabolism via pAMPK, SREBP-1, FAS and ACC; the oxidative response mediated by CYP2E1 or malonaldehyde production; TNF and IL-mediated inflammation and the fibrosis development induced by TGF-β/SMAD pathway [62].