OPN overexpression has been associated with worse prognosis in many cancers including glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, lung cancer, breast cancer, bladder cancer, melanoma, head and neck squamous cell carcinoma, and acute myeloid leukemia [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39]. This evidence concerns the gene SPP1 and acute myeloid leukemia.