SEPTIN5 and Alzheimer disease: Thus, given that Aβ-mediated synaptic dysfunction is one of the earliest features in AD [13] and that SEPTIN5 is known to regulate synaptic vesicle exocytosis and intracellular vesicular trafficking [10], it is essential to further elucidate the role of SEPTIN5 in the cellular processes relevant for AD, such as APP processing and the generation of Aβ.