Thus, given that Aβ-mediated synaptic dysfunction is one of the earliest features in AD [13] and that SEPTIN5 is known to regulate synaptic vesicle exocytosis and intracellular vesicular trafficking [10], it is essential to further elucidate the role of SEPTIN5 in the cellular processes relevant for AD, such as APP processing and the generation of Aβ. Here, APP is linked to Alzheimer disease.