Upregulation of oncosuppressor miR-7 negatively impacts the expression of target genes EGFR, IGF-1R and CRAF in vemurafenib-resistant cells of in vitro melanoma models or xenograft mice, which in turn inhibits the activation of MAPK and PI3K/AKT pathways, in this manner reversing melanoma cell resistance to BRAFi [122]. Here, AKT1 is linked to melanoma.