Hypoxia-inducible factor 1 alpha (HIF1α), key player in the cellular response to oxygen deprivation [95], promotes the expression of several miRNAs (miR-210, miR-218, miR-224, and miR-452) that contribute to tumour cell plasticity and aggressiveness, by targeting and increasing BNIP3 (BCL2/adenovirus E1B interacting protein 3), associated with glutamine metabolism [96,97,98]. Here, HIF1A is linked to neoplasm.