The oncogenic activity of antisense non-coding RNA in the INK4A locus (ANRIL) in melanoma revolves around the regulation of its encoding locus that also harbours the tumour suppressor genes INK4A and INK4B. In cutaneous melanoma tissue samples and cell lines, strong levels of ANRIL negatively modulated the expression of CDKN2A/2B proteins [78,79]. Here, CDKN2A is linked to cutaneous melanoma.