Loss of E-cadherin, coupled with the aberrant expression of N-cadherin and αVβ3 integrin seem to be crucial for the progression of melanoma to the final cutaneous stage, characterised by a vertical growth phase (VGP) into the dermis, where neoplastic melanocytes suffer mutations repressing apoptosis, in order to survive in the absence of keratinocytes [11,12]. This evidence concerns the gene CDH1 and melanoma.