IGHE and parasitic infectious disease: These results suggest that IgE-monocyte-mediated anti-tumour effects may be delivered via IgE Fc-mediated ADCC and an immune mediator milieu, including the pro-inflammatory TNFα and the monocyte chemoattractant MCP-1, contributing to an activation cascade analogous to that triggered in IgE-mediated protective responses against parasite infection [25].