Consistent with these findings, in a cohort of 1656 ovarian cancer patients [62], higher intratumoural expression of combined mediators found upregulated with monocyte activation by IgE (TNFα, MCP-1, IL-10, CXCL-10, IL-1β, IL-6 and IL-23) and in combination with key protein kinases downstream of FcεRI (LYN, FYN and FGR) and FcεRs were associated with more favourable five-year overall survival [12,44]. The gene discussed is IGHE; the disease is ovarian cancer.