Similarly, human U937 monocytic cells, which lack endogenous IgE bound on IgE Fc receptors prior to stimulation with anti-tumour IgE, also upregulated TNFα, MCP-1, and IL-10 expression with MOv18 IgE-dependent cytotoxic killing (ADCC) of tumour cells (Figure S5). The gene discussed is IGHE; the disease is neoplasm.