GLA and Fabry disease: Fabry disease is an X-linked lysosomal storage disease caused by mutations in the GLA gene encoding α-galactosidase A, which results in increased intracellular and circulating levels of enzyme substrates, such as globotriaosylceramide (Gb3), globotriaosylsphingosine (Lyso-Gb3), and galabiosylceramide [1].