Three different types of tau aggregates strongly correlate with neuronal degeneration: the neurofibrillary tangles (NFTs) in neuronal somata, which is the primary cause of neurodegeneration in a number of tauopathies, neuropil threads (NTs) in neuronal dendrites, and neuritic plaques (NPs) [58,59] (Figure 1A). Here, MAPT is linked to tauopathy.