In addition, we have recently demonstrated that plasma levels of soluble CD40 receptor (sCD40), a circulating isoform of the CD40 receptor and an endogenous antagonist, predict progression of renal dysfunction in patients with chronic kidney disease (CKD) on multiple (≥3) anti-hypertensive medications and that sCD40L is significantly elevated in these settings [24] (Table 1). The gene discussed is CD40LG; the disease is chronic kidney disease.