In fact, several studies show that both hypobaric hypoxia and oxidative stress can activate kinase proteins, such as Akt and p38α MAPK, and stabilize hypoxia-inducible transcription factor-1α (HIF-1α) [21,22], which are related to cardiac hypertrophy and ventricular remodeling [23,24,25,26]. The gene discussed is AKT1; the disease is cardiac hypertrophy.