Regarding metabolic factors, two interesting studies by Muthuramu et al. [72,73] in another hypertrophy model, transverse aortic constriction (TAC), showed through cholesterol and homocysteine lowering gene therapy the pivotal role of cholesterol and homocysteine levels in the development of metabolic cardiac hypertrophy, fibrosis and heart function related to oxidative stress and protein kinase activation. Here, WEE1 is linked to hypertrophy.