In addition, regarding this type of condition, an interesting study by Brown et al. [70] showed that mice with RVH induced by chronic hypobaric hypoxia showed a relation of MAP kinase kinase kinase-2 (MEKK-2) and the ERK5 pathway, leading to an increase in inflammatory molecules that triggered the cardiac hypertrophy process. Here, MAPK7 is linked to cardiac hypertrophy.