In addition, it was reported there exists an increased interaction of adenylate kinase 5 (AK5) with copine 6, in TLE patients and experimental epileptic rats, where the AK5-copine 6 complex could play an important role in regulating epileptic seizures and epileptogenesis [332], suggesting a new therapeutic targets for the treatment of epilepsy, particularly drug-resistant epilepsy. The gene discussed is AK5; the disease is epilepsy.